Sermorelin is a synthetic peptide meticulously prepared for scientific inquiry. This product is synthesized with high purity for laboratory investigations. It is developed for use in various research applications. Sermorelin is designated solely for research and development purposes.
Sermorelin's structure consists of the amino acid sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2, with a molecular formula of C149H246N44O42S and an approximate molecular weight of 3357.91 Da. As an amidated acetate salt form, it incorporates modifications that improve resistance to enzymatic degradation, allowing for more consistent activity in lab assays compared to native GHRH. This peptide shares structural homology with other members of the secretin/glucagon family, contributing to its receptor-specific binding profile.
In practical handling, sermorelin is typically supplied as a white lyophilized powder with purity levels exceeding 98%, confirmed by HPLC and mass spectrometry analysis. It exhibits good solubility in sterile water or neutral buffers, making it suitable for reconstitution in various experimental setups. Our commitment to integrity includes thorough testing for each batch, ensuring you receive a reliable product that supports precise and reproducible research outcomes.
Sermorelin is a synthetic 29-amino-acid peptide analog of the naturally occurring growth hormone-releasing hormone (GHRH), specifically mimicking the active N-terminal segment (GRF 1-29) to stimulate the pituitary gland's production and release of endogenous growth hormone (GH) in experimental models. Engineered for enhanced stability and potency, this peptide serves as a valuable probe for in-vitro investigations into endocrine regulation, metabolic processes, and growth dynamics, offering researchers a targeted approach without the complexities of full-length GHRH. As with all our peptides, sermorelin is provided strictly for research purposes and in-vitro use only—not for human consumption or any diagnostic or therapeutic applications.
Sermorelin functions by binding to the growth hormone-releasing hormone receptor (GHRHR) on pituitary somatotroph cells, mimicking native GHRH to trigger a cascade of intracellular signaling that culminates in the pulsatile release of GH. This activation enhances pituitary gene transcription of GH messenger RNA, thereby increasing the gland's reserve and promoting sustained hormone secretion without directly introducing exogenous GH. Downstream, the elevated GH levels can influence insulin-like growth factor-1 (IGF-1) production in peripheral tissues, supporting metabolic and anabolic processes in models.
Unlike broader-acting agents, sermorelin's specificity helps preserve natural feedback loops, potentially minimizing desensitization in prolonged assays. We're here to clarify these pathways—think of sermorelin as a gentle nudge to the endocrine system, allowing you to observe authentic physiological responses in your controlled environments.
In essence, sermorelin stands as a refined GHRH analog, empowering researchers to explore endogenous GH dynamics and their broader implications for metabolism, growth, and cellular health in precise experimental contexts. Its ability to mimic natural signaling pathways fuels our passion for peptide science, and we're proud to offer it with the transparency and quality that define us. Exclusively for in-vitro research, sermorelin reflects our humble yet confident approach to supporting your discoveries. Let's connect and advance knowledge together, one thoughtful study at a time.
Sermorelin's targeted stimulation of GH release positions it as a key resource for in-vitro and ex-vivo studies in endocrinology, metabolism, and aging. In pituitary cell cultures, it has been utilized to assess dose-dependent GH secretion and receptor kinetics, providing insights into somatotroph function and transcriptional regulation. Metabolism-focused assays often employ sermorelin to explore its effects on lipid and glucose homeostasis, with models demonstrating potential improvements in insulin sensitivity and energy balance.
Researchers have also applied it in neurodegeneration models, where it probes neurotrophic effects via GH/IGF-1 axes, potentially mitigating oxidative stress in neuronal cultures. In anti-doping and pharmacology screens, sermorelin serves as a reference for detecting GHRH analogs through in-vitro metabolism studies, identifying stable fragments for analytical purposes. We encourage its use in combination with other secretagogues for synergistic assays, and our team can share logical protocol ideas to help you uncover meaningful data responsibly.
Proper storage is crucial to maintain sermorelin's stability for your in-vitro work—keep the lyophilized powder at room temperature (20-25°C) in a dry, dark place before reconstitution, but once mixed, refrigerate at 2-8°C and do not freeze to avoid degradation. For reconstitution, use sterile bacteriostatic water or a neutral buffer to achieve concentrations of 1-2 mg/mL, gently swirling to dissolve without foaming. Reconstituted solutions remain viable for up to 90 days under refrigeration, but aliquot to minimize exposure.
Our quality processes include stability verification, but always inspect for clarity before use. If travel is needed, a cooler with ice packs can temporarily substitute refrigeration. We're your steady guide for any handling nuances—just ask.
Sermorelin is a synthetic 29-amino-acid peptide analog of the naturally occurring growth hormone-releasing hormone (GHRH), specifically mimicking the active N-terminal segment (GRF 1-29) to stimulate the pituitary gland's production and release of endogenous growth hormone (GH) in experimental models. Engineered for enhanced stability and potency, this peptide serves as a valuable probe for in-vitro investigations into endocrine regulation, metabolic processes, and growth dynamics, offering researchers a targeted approach without the complexities of full-length GHRH. As with all our peptides, sermorelin is provided strictly for research purposes and in-vitro use only—not for human consumption or any diagnostic or therapeutic applications.
Sermorelin functions by binding to the growth hormone-releasing hormone receptor (GHRHR) on pituitary somatotroph cells, mimicking native GHRH to trigger a cascade of intracellular signaling that culminates in the pulsatile release of GH. This activation enhances pituitary gene transcription of GH messenger RNA, thereby increasing the gland's reserve and promoting sustained hormone secretion without directly introducing exogenous GH. Downstream, the elevated GH levels can influence insulin-like growth factor-1 (IGF-1) production in peripheral tissues, supporting metabolic and anabolic processes in models.
Unlike broader-acting agents, sermorelin's specificity helps preserve natural feedback loops, potentially minimizing desensitization in prolonged assays. We're here to clarify these pathways—think of sermorelin as a gentle nudge to the endocrine system, allowing you to observe authentic physiological responses in your controlled environments.
In essence, sermorelin stands as a refined GHRH analog, empowering researchers to explore endogenous GH dynamics and their broader implications for metabolism, growth, and cellular health in precise experimental contexts. Its ability to mimic natural signaling pathways fuels our passion for peptide science, and we're proud to offer it with the transparency and quality that define us. Exclusively for in-vitro research, sermorelin reflects our humble yet confident approach to supporting your discoveries. Let's connect and advance knowledge together, one thoughtful study at a time.
Sermorelin's structure consists of the amino acid sequence Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2, with a molecular formula of C149H246N44O42S and an approximate molecular weight of 3357.91 Da. As an amidated acetate salt form, it incorporates modifications that improve resistance to enzymatic degradation, allowing for more consistent activity in lab assays compared to native GHRH. This peptide shares structural homology with other members of the secretin/glucagon family, contributing to its receptor-specific binding profile.
In practical handling, sermorelin is typically supplied as a white lyophilized powder with purity levels exceeding 98%, confirmed by HPLC and mass spectrometry analysis. It exhibits good solubility in sterile water or neutral buffers, making it suitable for reconstitution in various experimental setups. Our commitment to integrity includes thorough testing for each batch, ensuring you receive a reliable product that supports precise and reproducible research outcomes.
Sermorelin's targeted stimulation of GH release positions it as a key resource for in-vitro and ex-vivo studies in endocrinology, metabolism, and aging. In pituitary cell cultures, it has been utilized to assess dose-dependent GH secretion and receptor kinetics, providing insights into somatotroph function and transcriptional regulation. Metabolism-focused assays often employ sermorelin to explore its effects on lipid and glucose homeostasis, with models demonstrating potential improvements in insulin sensitivity and energy balance.
Researchers have also applied it in neurodegeneration models, where it probes neurotrophic effects via GH/IGF-1 axes, potentially mitigating oxidative stress in neuronal cultures. In anti-doping and pharmacology screens, sermorelin serves as a reference for detecting GHRH analogs through in-vitro metabolism studies, identifying stable fragments for analytical purposes. We encourage its use in combination with other secretagogues for synergistic assays, and our team can share logical protocol ideas to help you uncover meaningful data responsibly.
Proper storage is crucial to maintain sermorelin's stability for your in-vitro work—keep the lyophilized powder at room temperature (20-25°C) in a dry, dark place before reconstitution, but once mixed, refrigerate at 2-8°C and do not freeze to avoid degradation. For reconstitution, use sterile bacteriostatic water or a neutral buffer to achieve concentrations of 1-2 mg/mL, gently swirling to dissolve without foaming. Reconstituted solutions remain viable for up to 90 days under refrigeration, but aliquot to minimize exposure.
Our quality processes include stability verification, but always inspect for clarity before use. If travel is needed, a cooler with ice packs can temporarily substitute refrigeration. We're your steady guide for any handling nuances—just ask.
